IMAGE: Conceptual diagram of bio-organizational crushing know-how primarily based on high-intensity concentric ultrasonography
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Credit score: Korea Institue of Science and Expertise(KIST)

Focusing ultrasound power on a goal web site within the physique to generate warmth can burn and destroy the tissue within the web site and not using a surgical process. This methodology is clinically utilized to deal with uterine fibroids, prostatic hyperplasia, prostate most cancers, metastatic bone tumor and different forms of tumor to destroy tumor cells utilizing warmth. Nevertheless, there’s a potential downside that the encompassing tissue could also be burned within the course of as a consequence of warmth diffusion.

In 2019, on the Korea Institute of Science and Technology (KIST) Middle for Bionics, Dr. Ki Joo Pahk’s analysis group confirmed the opportunity of exactly fractionating goal tumor cells, as if it’s minimize out utilizing a knife, with out inflicting warmth injury to every other a part of the physique through the use of high-intensity targeted ultrasound (HIFU), an ultrasound with an acoustic stress in megapascals (MPa) that’s way more highly effective than present ultrasound, and revealed the mechanism behind the process.(?Ultrasonics Sonochemistry. 2019, 53, 164-177)

Within the strategy of bodily destroying the tissue with out the usage of warmth, a boiling vapor bubble is generated on the goal web site of the HIFU, and it’s by the kinetic power of this major vapor bubble that the goal tumor tissue will get destroyed. Nevertheless, through the course of, cavitation bubble clouds might be subsequently generated between the boiling bubble and the HIFU transducer, resulting in undesirable cell destruction. This made it essential to determine the reason for their formation and to precisely predict the areas of their prevalence.

So as to reveal the mechanism of cavitation bubble clouds formation occurring when tumor tissue is eliminated by HIFU, the analysis group at KIST developed a mathematical mannequin as a part of their follow-up examine and examined the affect of the first boiling vapor bubble on nonlinear wave propagation. The outcomes confirmed that the secondary era of bubbles was attributable to a constructive interference of the backscattered shockwave by the boiling bubble with the incoming incident shockwaves and it’s throughout the vary of this interference that the secondary bubbles fashioned. Based mostly on the photographs obtained utilizing a high-speed digital camera, it was discovered that the world the place the interference occurred and the world the place the secondary bubbles have been generated have been intently matched.

These findings not solely clarify the mechanism behind the secondary bubbles formation but additionally assist predict the place they may happen, thereby presenting the opportunity of destroying goal tissue with better security and precision.

Dr. Pahk from KIST mentioned, “This examine has proven that cavitation bubble clouds might be subsequently generated on account of a shock scattering impact after a boiling vapor bubble types the place the ultrasound is targeted. Utilizing the mathematical developed on this examine, will probably be attainable to foretell the areas of bubble formation and the potential web site that will get destroyed. I hope that the ultrasound know-how beneath improvement might be developed in an ultra-precision targeted ultrasound know-how enabling bodily destruction of solely the tumor tissue, with out the necessity for surgical procedure, in order that it may be utilized clinically sooner or later.”


This examine was carried out with a grant from the Ministry of Science and ICT (MSIT), as a part of the Institutional R&D Program of KIST and the Inventive Convergence Analysis Program of the Nationwide Analysis Council of Science & Expertise (NST). It was revealed within the newest version of Ultrasonics Sonochemistry (IF: 6.513, High 1.562% within the discipline of JCR), a number one worldwide journal within the discipline of acoustics.

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